Table 3.
Univariate and multivariable analyses* of the 11-protein signature for its prognostic value (n = 63)
| Test set (multicenter cohort) | Metastasis-free survival | Breast cancer–related survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariable analysis | Univariate analysis | Multivariable analysis | |||||
| Variables | Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P |
| Age, y | 0.99 (0.95 to 1.02) | .42 | 1.02 (0.96 to 1.07) | .59 | 0.99 (0.95 to 1.03) | .68 | 1.02 (0.96 to 1.08) | .61 |
| Menopausal status, post- vs premenopausal | 0.60 (0.24 to 1.48) | .27 | 0.41 (0.08 to 1.96) | .26 | 0.71 (0.27 to 1.89) | .49 | 0.50 (0.09 to 2.66) | .42 |
| Tumor size, >2cm & unknown vs ≤2 cm | 0.74 (0.30 to 1.83) | .51 | 0.70 (0.28 to 1.75) | .45 | 0.94 (0.34 to 2.60) | .91 | 0.93 (0.34 to 2.58) | .89 |
| Tumor grade† | ||||||||
| Grade 3 vs 1 and 2 | 2.79 (0.64 to 12.22) | .17 | 3.22 (0.71 to 14.52) | .13 | 2.09 (0.47 to 9.33) | .34 | 2.31 (0.50 to 10.75) | .29 |
| Grade unknown vs 1 and 2 | 2.61 (0.37 to 18.55) | .34 | 2.70 (0.37 to 19.80) | .33 | 2.67 (0.37 to 19.05) | .33 | 2.88 (0.39 to 21.48) | .30 |
| 11-protein signature, predicted poor vs good | 13.15 (3.03 to 57.07) | .001 | 12.45 (2.67 to 58.11) | .001 | 22.78 (3.00 to 173.08) | .003 | 36.08 (4.00 to 325.67) | .001 |
* Univariate and multivariable analyses were performed based on Cox regression model. All statistical tests were two-sided. CI = confidence interval
† Tumor grade classification according to Bloom and Richardson scoring system (34).