Table 1.

Mean demographic and biomarker data.

Variable at baseline	NC N = 111	MCI N = 182	AD N = 95	One-way ANOVA/chi squared test, p-value
Age, years	75.5 (5.2)	74.2 (7.4)	74.6 (7.9)	0.3
Gender, M:F	56:55	121:61	55:40	0.023
Education, years	15.8 (2.8)	15.8 (3.0)	15.3 (3.0)	0.3
MMSE	29.1 (1.0)	26.9 (1.8)	23.6 (1.9)	< 0.001
CSF Aβ42 level, pg/ml	206 (55)	163 (55)	143 (40)	< 0.001
CSF t-tau level, pg/ml	69 (30)	103 (61)	124 (58)	< 0.001
CSF p-tau181 level, pg/ml	25 (15)	35 (18)	43 (20)	< 0.001
Mean hippocampal volume, mm3	4100 (586)	3779 (631)	3518 (604)	< 0.001
ApoE4 positive subjects
Variable at baseline	NC N = 27	MCI N = 99	AD N = 65	One-way ANOVA/chi squared test, p-value
Age, years	75.8 (5.8)	73.5 (6.6)	74.0 (7.4)	0.3
Gender, M:F	18:9	60:39	39:26	0.8
Education, years	15.6 (2.8)	15.7 (2.8)	14.8 (3.0)	0.2
MMSE	28.9 (1.1)	27.0 (1.8)	23.6 (1.9)	< 0.001
CSF Aβ42 level, pg/ml	157(49)	143 (41)	131 (27)	0.012
CSF t-tau level, pg/ml	80 (40)	117 (67)	122 (53)	0.007
CSF p-tau181 level, pg/ml	32 (21)	40 (18)	43 (19)	0.05
Mean hippocampal volume, mm3	4175 (443)	3708 (608)	3476 (608)	< 0.001
ApoE4 negative subjects
Variable at baseline	NC N = 84	MCI N = 83	AD N = 30	One-way ANOVA/chi squared test, p-value
Age, years	75.4 (5.0)	74.9 (8.2)	75.9 (8.9)	0.8
Gender, M:F	38:46	61:22	14:16	0.001
Education, years	15.8 (2.7)	16.0 (3.2)	16.3 (2.8)	0.7
MMSE	29.1 (1.0)	26.8 (1.8)	23.5 (1.9)	< 0.001
CSF Aβ42 level, pg/ml	222 (48)	187 (60)	168 (52)	< 0.001
CSF t-tau level, pg/ml	65 (25)	85 (48)	127 (69)	< 0.001
CSF p-tau181 level, pg/ml	22 (11)	30 (16)	42 (22)	< 0.001
Mean hippocampal volume, mm3	4077 (625)	3731 (573)	3610 (564)	< 0.001

Bold values indicate significance at p < 0.05.