Skip to main content
. Author manuscript; available in PMC: 2015 Feb 28.
Published in final edited form as: J Control Release. 2013 Dec 24;176:35–43. doi: 10.1016/j.jconrel.2013.12.012

Figure 8.

Figure 8

Impact of aminoglycoside-derived polymers, Pa-GDGE and Pa-BDGE, on adenoviral infectivity in vitro. (A) MB49 cells were transduced with 20 MOI in absence or presence of the highest non-toxic dose of polymer: aparmycin-GDGE (60 ug/ml), paromomycin-GDGE (60ug/ml), paromomycin-BDGE (60ug/ml), amikacin (30ug/ml), neomycin-CDDE (20ug/ml) or amicacin-NPGDE (10 ug/ml). Data shown are the mean ± SD from three independently performed experiments. (B) MB49 cells were infected with 20 MOI AdGFP in the absence or presence of increasing concentrations of paromomycin-GDGE or -BDGE. Data shown are the mean ± SD from two independently performed experiments. (C) MB49 cells were transduced with increasing concentrations of AdGFP in the absence or presence of 30 μg/ml paromomycin-GDGE or -BDGE. At 48 hours post-infection, the number of GFP positive cells was determined by flow cytometry. Data shown are the mean ± SD from three independently performed experiments. GFP expression was quantified by flow cytometry at 48 hours.