Table 1.

Toxicity of aminoglycoside polymers. Toxicity (% death) was determined by 7-AAD staining at 24 hours. Data are the mean ± SD from at least 3 independent experiments.

Polymer name	7AAD assay	Concentration
No polymer	0.65 ± 0.33	NA
Aparmycin-RDGE	2.93 ± 1.83	60 mg/ml
Aparmycin-GDGE	1.96 ± 1.49	60 mg/ml
Paromomycin-GDGE	3.97 ± 0.74	60 mg/ml
Neomycin-GDGE	6.30 ± 0.99	40 mg/ml
Sisomicin-GDGE	4.35 ± 0.38	60 mg/ml
Kanamycin-GDGE	3.65 ± 2.74	30 mg/ml
Neomycin-CDDE	4.19 ± 2.35	20 mg/ml
Amikacin-CDDE	7.53 ± 6.41	30 mg/ml
Paromomycin CDDE	5.71 ± 2.09	20 mg/ml
Sisomicin-CDDE	3.51 ± 1.00	20 mg/ml
Amikacin-NPGDE	3.92 ± 3.88	10 mg/ml
Kanamycin-BDGE	5.00 ± 1.13	60 mg/ml
Paromomycin-BDGE	1.58 ± 0.85	60 mg/ml
Amikacin-EDGE	4.03 ± 0.56	60 mg/ml
Neomycin-EDGE	6.55 ± 2.21	60 mg/ml
Paromomycin-EGDE	1.65 ± 1.06	60 mg/ml