Table 1.
Chromatin-modifying enzymes
| Enzyme | Writer/eraser | Chromatin modification | Transcriptional outcome |
|---|---|---|---|
| MLL1, 2, 3, 4, 5 | Writer | H3K4me | Activation |
| DOT1L | Writer | H3K79me | Activation |
| PRMT1 | Writer | H4R3me2a | Activation |
| p300 | Writer | H3acH4ac | Activation |
| MOZ | Writer | H3ac | Activation |
| PCAF | Writer | H3ac | Activation |
| EZH2 | Writer | H3K27me | Repression |
| HDAC1, 2, 3 | Eraser | H3acH4ac | Repression |
| KDM1A (LSD1) | Eraser | H3K4meH3K9me | Repression |
| KDM5A (JARID1A) | Eraser | H3K4me | Repression |
| PRMT6 | Writer | H3R2me2a | Repression |
| DNMT1, 3a, 3b | Writer | 5mC | Repression |
| Tet1, 2, 3 | Writer/eraser | 5hmC/5mC | TBD |
| AID | Eraser | 5mC | TBD |
AID, activation-induced cytidine deaminase; TBD, to be determined.