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. Author manuscript; available in PMC: 2014 Mar 13.
Published in final edited form as: Trends Cancer Res. 2013 Jan 1;9:1–13.

Figure 2.

Figure 2

TLR4 Signaling Pathway. LPS-induced activation of TLR4 is mediated by CD14. CD14 delivers LPS to TLR4/MD-2 complex and downstream signaling is divided into MyD88-dependent and independent signaling. MyD88-dependent signaling results in the rapid activation of NF-κB and the induction of pro-inflammatory cytokines, while MyD88-independent signaling results in late activation of NF-κB and induction of type I interferons.