B. Multivariate survival analysis

	OS			PFS
	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
Overall cohort
IPI >2	3.04	1.96-3.96	<.0001	2.59	1.8-3.62	<.0001
B-symptoms	1.43	1.00-2.04	.048	1.49	1.06-2.10	.024
TP53 mutation	1.59	1.06-2.26	.013	1.52	1.03-2.17	.023
MUT-p53 subcohort
IPI >2	2.03	1.05-3.93	.035	1.95	1.02-3.74	.042
p53 >10%	2.70	1.04-7.04	.042	2.87	1.10-7.45	.031
MDM2 >10%	2.24	1.17-4.27	.015	1.96	1.03-3.70	.041

LDH, lactate dehydrogenase; CR, complete remission; PR, partial response; SD, stable disease; PD, progressive disease.

For therapy response, we calculated P values as CR vs other responses. Some clinical features of certain cases were not available.