Table 1.
Functional Annotation Clustering Analysis by Gene Ontology Classificationa of Significant Gene Expression Differences Identified by Transcriptional Profiling of HIV-1–Infected and Control MDM Stimulated With M. tuberculosis for 24 hours (in 3 Separate Experiments), Showing the Top 10 Gene Ontology Terms
| Term | % of Gene List | P Value | Fold Enrichment |
|---|---|---|---|
| GO:0006955∼immune response | 32.7 | 3.8 × 10−11 | 7.5 |
| GO:0005125∼cytokine activity | 21.8 | 4.3 × 10−11 | 17.4 |
| GO:0042330∼taxis | 20.0 | 1.1 × 10−10 | 19.8 |
| GO:0006935∼chemotaxis | 20.0 | 1.1 × 10−10 | 19.8 |
| GO:0005615∼extracellular space | 30.9 | 1.2 × 10−09 | 6.6 |
| GO:0044421∼extracellular region part | 34.5 | 2.8 × 10−09 | 5.3 |
| GO:0006954∼inflammatory response | 21.8 | 8.2 × 10−09 | 10.6 |
| GO:0006952∼defense response | 27.3 | 8.7 × 10−09 | 7.0 |
| GO:0008009∼chemokine activity | 12.7 | 1.0 × 10−08 | 42.9 |
| GO:0042379∼chemokine receptor binding | 12.7 | 1.5 × 10−08 | 40.3 |
Abbreviations: GO, gene oncology; HIV, human immunodeficiency virus; MDM, monocyte-derived macrophages; Mtb, M. tuberculosis.