Table 2.

VWD diagnostic approaches

VWD diagnostic strategy
Clinical phenotype	Increasing use of quantitative bleeding assessment tools; eg, ISTH-BAT
Hemostasis laboratory	• VWF:Ag
phenotype	• VWF:RCo: possibility of substituting a direct GPIb-binding assay
	• VWF:CB combination of collagens I and III
	• VWF:F8
	• VWFpp: aids in identification of accelerated clearance variants
	• VWF multimer profile
	• Ristocetin-induced platelet agglutination (RIPA)
Genotype	• Type 1 VWD: premature for routine use, may be helpful in the future
	• Type 2A: not usually needed
	• Type 2B: helpful confirmation and rules out PT-VWD
	• Type 2M: sometimes helpful
	• Type 2N: definitive differentiation from mild hemophilia A
	• Type 3: very helpful for genetic counseling

VWFpp indicates VWF propeptide; and PT-VWD, platelet-type VWD.