Figure 10.

DNA fragmentation and cell death assessed after exposure of cells to LC at 10% (LC10) of AlPc-NPs for 15 minutes followed by the application of light (laser, λ 670 nm) at different energy densities in vitro.

Notes: (A) DNA fragmentation and (B) cell death. The values of LC₅₀ for 4T1, NIH/3T3, MCF-7, and MCF-10A were 0.31 μM AlPc, 0.63 μM AlPc, 0.46 μM AlPc, and 1.80 μM AlPc, respectively. (A) The difference between pairs of means in the same graph identified with different letters are statistically significant (P<0.05). (B) *Groups presenting with a statistically significant difference between the means for apoptosis and necrosis; no statistically significant differences were observed between the results of different cell lineages of the same origin.

Abbreviations: NPs, nanoparticles; LC, lethal concentrations; AlPc, aluminum–phthalocyanine chloride.