Figure 2. Comprehensive genetic analysis of bipolar disorder in a genetic isolate.

Pipeline for the integrative analysis of microsatellite, SNP genotype and whole-genome sequence data. Linkage analysis of the ∼2K microsatellite markers is performed to identify genomic regions with evidence for linkage and to identify the nuclear families and specific haplotypes responsible for each linkage signal. Variants segregating on these haplotypes were then identified by phasing and imputation of variants found by whole-genome sequencing. In the final step, family-based association analysis is performed specifically on these variants.