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WBCT of rFVIIIFc and rFVIII in hemophilia A dogs. Normal WBCT range in dogs is shown by the large dashed lines. The area above the small dashed lines (20 minutes) indicates the point at which the plasma FVIII activity is expected to be below 1% of normal. WBCT in hemophilia A dogs of rFVIIIFc (A) and rFVIII followed by rFVIIIFc in a crossover study (B).
