Table 3.

Summary of PK parameters for rFVIIIFc and rFVIII in hemophilia A dogs

Treatment	Cmax, IU/mL	Cmax, ng/mL	AUC, h × IU/mL	AUC, h × ng/mL	T1/2, h	CL, mL/h/kg	Vss, mL/kg
PK by FVIII activity measurement
rFVIIIFc*	2.0 ± 0.54		25.9 ± 6.47		15.4 ± 0.3	5.1 ± 1.4	86.4 ± 14.0
rFVIII†	2.0		18.2		7.4	6.5	64.0
PK by rFVIII and rFVIIIFc Ag measurement
rFVIIIFc*		210 ± 33		2481 ± 970	15.7 ± 1.7	6.2 ± 3.0	86.1 ± 19.2
rFVIII†		211		1545	6.9	8.7	80.7

See Table 2 for expansion of abbreviations.

^*Results presented are mean ± SD from 4 dogs.

^†Results presented are mean. SD not reported since 2 dogs were used.