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. 2014 Mar 13;9(3):e90933. doi: 10.1371/journal.pone.0090933

Figure 4. Actin polymerization is involved in NTHi-induced human β-defensin 2 up-regulation.

Figure 4

(A) Gentamicin protection assays show that cytochalasin D (CytD), an inhibitor of actin polymerization, inhibits internalization of live NTHi into the HMEEC cells. (B) Quantitative RT-PCR analysis shows that NTHi lysate-induced human β-defensin 2 up-regulation is suppressed by the treatment with CytD in the HMEEC cells. DEFB4: human β-defensin 2. Results were expressed as fold-induction, taking the value of the non-treated group as 1. The experiments were performed in triplicate and repeated twice. Values are given as the mean ± standard deviation (n = 3). *: p<0.05.