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. 2014 Jan 27;289(11):7448–7459. doi: 10.1074/jbc.M113.543926

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Altered gene pathways in drim2 KO Drosophila. Heat map representing a selection of deregulated transcripts, provided by DAVID tool, in drim2^−/− versus drim2^+/− involved in purine (22 transcripts) and pyrimidine (13 transcripts) metabolism (A and B, respectively), as well in oxidative phosphorylation (10 transcripts) and glycolysis/gluconeogenesis (six transcripts) (C and D, respectively). A color-coded scale for the normalized expression values is used as follows: yellow and blue represent high and low expression levels in drim2^−/− with respect to drim2^+/−, respectively. The expression level of each transcript was calculated as the log2 (drim2^−/−/ drim2^+/−), and the complete list of differentially expressed genes identified by Significance Analysis of Microarray algorithm is provided in the supplemental Table S1.