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. 2014 Feb 3;289(11):7558–7568. doi: 10.1074/jbc.M113.543884

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Intracellular distribution of Dorsal in fat body cells. A and B, immunohistochemistry staining revealed a substantial nuclear accumulation of Dorsal protein in dronc^ΔA8 fat body cells. Images show the maximal projection of multiple confocal images. C–E, the enzymatic activity of Dronc plays an essential role in repressing spontaneous activation of the Toll/Dorsal cascade. The details are described in the text. The genotypes were Act5c-Gal4/+; dronc^ΔA8/dronc^ΔA8 (C); Act5c-Gal4/UAS-dronc^wt-FLAG; dronc^ΔA8/dronc^ΔA8 (D); and Act5c-Gal4/UAS-dronc^C318A; dronc^ΔA8/dronc^ΔA8 (E). F and G, immunohistochemical staining of Dorsal; spz^rm7 and Toll^10b (Tl^10b) mutants were used as negative and positive controls, respectively. H, dorsal nuclear translocation in the fat bodies of other apoptosis-deficient mutants was observed to various extents. The penetrance of Dorsal nuclear staining among the tested larvae is indicated as a percentage in the top right corner of each panel. Scale bar, 20 μm.