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Rodent meprin A and meprin B decrease the bioactivity of murine IL-6. Recombinant mouse and rat meprin A and B (0.1 μm each) were incubated with murine IL-6 (1 μm) for 5–120 min, as indicated on the x axis. The percentage of activity of the meprin-cleaved IL-6 was determined by comparing the proliferation of B9 cells incubated with meprin-cleaved IL-6 with the proliferation of B9 cells incubated with uncleaved IL-6 (which was considered 100% activity) (n = 3).
