FIGURE 3.

The Nlrp3 inflammasome is required in DCs for mediating the immunogenic activity of HMGB1. A–D, the DTH assay was conducted as in Fig. 2B using TNP-conjugated WT, Asc^−/−, Nlrp3^−/−, Aim2^−/−, or Nlrc4^−/− CD8α⁺ DCs fed apoptotic splenocytes in the absence or presence of full-length WT HMGB1 or the A-box peptide. No treat, no treatment.