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Three-dimensional view of the interface between Fc-YTE (pink), FcRn α-chain (green), and β2-microglobulin (blue) around Fc-YTE Glu256. The side chain of Glu256 allows additional interactions with β2-microglobulin Gln2 (dotted lines). Thr254/Oγ1 also interacts with FcRn Glu133/Oϵ1. These interactions likely contribute to the high affinity of Fc-YTE for FcRn.
