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Engagement of SR-A in enhanced CD4+ T-cell activation by Pyr-OVA. CD4+ T-cells isolated from OT-II mice were co-cultured with wild-type or SR-A-deficient BMDCs in the presence of 20, or 200 μg/ml of native OVA, AGE-OVA, or Pyr-OVA for 24 h. Concentrations of IL-2 in culture supernatants were measured by ELISA. *, p < 0.001. The data are representative of two independent experiments.
