Table 3. Anatomical pattern of recurrence stratified by treatment with craniospinal irradiation across medulloblastoma subgroups combining all three cohorts.

SHH (p=0.83)	Local	Mixed	Metastatic
Chemotherapy (n = 20)	14 (70%)	1 (5%)	5 (25%)
CSI+/-Chemotherapy (n = 38)	26 (68·4%)	4 (10·5%)	8 (21·1%)
Group 3 (p=0.32)
Chemotherapy (n = 19)	2 (10%)	7 (35%)	11 (55%)
CSI+/-Chemotherapy (n = 48)	4 (8·3%)	9 (18.8%)	35 (72·9%)
Group 4 (p=0.031)
Chemotherapy (n = 8)	3 (37·5%)	2 (25%)	3 (38%)
CSI+/-Chemotherapy (n = 59)	4 (6·8%)	12 (20%)	43 (73%)

p-values determined by the Fisher's exact test; comparison of local vs mixed vs metastatic pattern of recurrence.

Note: Two patients in Validation Cohort 1 received focal RT with chemotherapy, one SHH with a metastatic recurrence and one Group 4 with a metastatic recurrence. Both cases are included in the chemotherapy only category. CSI=Craniospinal Irradiation