Table 2. L. interrogans sv. Copenhageni genes upregulated in DMCs compared to in vitro.
| Gene ID1 | Product1 | Fold (DMC vs IV) | P value (adjusted) | |
| Hypothetical Proteins | ||||
| LIC10822 | Hypothetical protein | ND @ 30°C | 4.00E-02 | |
| LIC12077 | Hypothetical protein | 22.78 | 1.19E-18 | |
| LIC13005 | Hypothetical protein | 21.12 | 2.75E-04 | |
| LIC13445 | Hypothetical protein | 17.46 | 6.13E-06 | |
| LIC11059 | Hypothetical protein | 16.76 | 2.65E-13 | |
| LIC10456 | Hypothetical protein | 10.59 | 4.12E-02 | |
| LIC10965 | Hypothetical protein | 9.73 | 8.94E-08 | |
| LIC12340 | Hypothetical protein | 7.14 | 3.40E-10 | |
| LIC13390 | Hypothetical protein | 6.60 | 2.74E-04 | |
| LIC10455 | Hypothetical protein | 6.54 | 1.04E-02 | |
| LIC12120 | Hypothetical protein | 6.20 | 1.93E-02 | |
| LIC10376 | Hypothetical protein | 6.14 | 2.07E-02 | |
| LIC11888 | Hypothetical protein | 5.71 | 1.33E-08 | |
| LIC10535 | Hypothetical protein | 5.61 | 2.65E-02 | |
| LIC12555 | Hypothetical protein | 4.76 | 5.29E-04 | |
| LIC10971 | Hypothetical protein | 4.35 | 8.70E-03 | |
| LIC10775 | Hypothetical protein | 4.27 | 8.69E-07 | |
| LIC10790 | Hypothetical protein | 4.15 | 8.98E-03 | |
| LIC11695 | Hypothetical protein | 4.06 | 9.65E-03 | |
| LIC11492 | Hypothetical protein | 4.03 | 4.56E-02 | |
| LIC12986 | Hypothetical protein | 4.03 | 2.53E-02 | |
| LIC10415 | Hypothetical protein | 3.93 | 5.73E-06 | |
| LIC13354 | Hypothetical protein | 3.77 | 4.53E-03 | |
| LIC12653 | Hypothetical protein | 3.63 | 5.83E-03 | |
| LIC12993 | Hypothetical protein | 3.53 | 1.19E-03 | |
| LIC10593 | Hypothetical protein | 3.32 | 3.07E-03 | |
| LIC11705 | Hypothetical protein | 3.14 | 3.55E-02 | |
| LIC10080 | Hypothetical protein | 3.14 | 5.99E-03 | |
| LIC10374 | Hypothetical protein | 3.09 | 2.12E-02 | |
| LIC10729 | Hypothetical protein | 2.97 | 2.12E-02 | |
| LIC10450 | Hypothetical protein | 2.94 | 1.21E-02 | |
| LIC10454 | Hypothetical protein | 2.86 | 4.53E-02 | |
| LIC11783 | Hypothetical protein | 2.82 | 4.12E-02 | |
| LIC10053 | Hypothetical protein | 2.81 | 1.23E-02 | |
| LIC10460 | Hypothetical protein | 2.74 | 5.31E-03 | |
| LIC13084 | Hypothetical protein | 2.72 | 2.03E-02 | |
| LIC12263 | ompL37 | Hypothetical protein | 2.67 | 8.81E-03 |
| LIC20245 | Hypothetical protein | 2.66 | 4.04E-02 | |
| LIC12719 | Hypothetical protein | 2.66 | 2.24E-02 | |
| LIC11275 | Hypothetical protein | 2.66 | 3.36E-02 | |
| LIC13212 | Hypothetical protein | 2.61 | 3.75E-02 | |
| LIC12353 | Hypothetical protein | 2.53 | 4.28E-02 | |
| LIC11565 | Hypothetical protein | 2.52 | 2.11E-02 | |
| LIC10050 | Hypothetical protein with OmpA-like domain | 2.46 | 1.54E-02 | |
| LIC11177 | Hypothetical protein | 2.43 | 2.67E-02 | |
| LIC11447 | Hypothetical protein | 2.42 | 3.36E-02 | |
| LIC10302 | Hypothetical protein | 2.23 | 2.28E-02 | |
| LIC12071 | Hypothetical protein | 2.08 | 3.02E-02 | |
| Putative or Probable Lipoproteins (unknown function) | ||||
| LIC12099 | lipL53 | Lipoprotein | 19.50 | 1.03E-26 |
| LIC11030 | Lipoprotein | 11.18 | 1.78E-04 | |
| LIC12209 | Lipoprotein | 7.76 | 2.75E-15 | |
| LIC11058 | lemA | Lipoprotein | 6.27 | 8.69E-07 |
| LIC10373 | Lipoprotein | 5.37 | 4.61E-11 | |
| LIC13066 | Lipoprotein | 5.34 | 3.09E-09 | |
| LIC10462 | Lipoprotein2 | 5.08 | 3.17E-07 | |
| LIC10371 | Lipoprotein | 4.61 | 9.64E-08 | |
| LIC10054 | rlpA | Lipoprotein | 3.84 | 1.44E-05 |
| LIC13355 | Lipoprotein | 3.72 | 1.25E-02 | |
| LIC12208 | Lipoprotein | 3.64 | 2.07E-04 | |
| LIC10461 | Lipoprotein | 3.54 | 1.84E-04 | |
| LIC10968 | Lipoprotein2 | 3.44 | 2.81E-03 | |
| LIC10463 | Lipoprotein | 3.31 | 4.81E-04 | |
| LIC11082 | Lipoprotein | 3.15 | 2.03E-03 | |
| LIC11167 | Lipoprotein | 2.24 | 2.03E-02 | |
| Pathogenicity and/or Virulence | ||||
| LIC12760 | colA | Collagenase precursor | 49.03 | 2.63E-51 |
| LIC12631 | sph2 | Hemolysin/sphingomyelinase-like protein, Sph2 | 13.92 | 5.13E-26 |
| LIC11219 | ahpC | Peroxiredoxin | 5.96 | 7.29E-07 |
| LIC10465 | ligA | Leptospira Ig-like protein LigA3 | 4.57 | 2.03E-02 |
| LIC12632 | sph1 | Hemolysin/sphingomyelinase-like protein, Sph1 | 4.02 | 1.52E-05 |
| LIC12927 | Cytochrome c peroxidase2 | 4.23 | 1.04E-05 | |
| LIC13198 | sph3 | Hemolysin/sphingomyelinase-like protein, Sph3 | 3.57 | 1.99E-02 |
| LIC12659 | vapB | Virulence-associated protein | 2.90 | 2.66E-02 |
| Chemotaxis and Motility | ||||
| LIC10299 | flgB | Flagellar basal body rod protein FlgB | 7.89 | 4.89E-16 |
| LIC11889 | flaB | Flagellin protein | 3.95 | 1.50E-02 |
| LIC10298 | flgC | Flagellar basal body rod protein FlgC | 3.91 | 2.12E-05 |
| LIC11328 | flgJ | Flagellum-specific muramidase | 3.89 | 7.28E-03 |
| LIC10297 | fliE | Flagellar hook-basal body protein FliE | 3.16 | 1.87E-03 |
| LIC11326 | flgH | Flagellar L-ring protein precursor | 2.66 | 3.03E-02 |
| LIC11186 | flbC | Flagellar protein | 2.37 | 3.72E-02 |
| Regulatory Functions | ||||
| LIC12798 | TetR family transcriptional regulator | 5.64 | 3.65E-05 | |
| LIC11146 | DeoR family transcriptional regulator | 4.42 | 3.08E-03 | |
| LIC12034 | fur | Fur family transcriptional regulator | 3.83 | 7.84E-04 |
| LIC11440 | Histidine kinase response regulator hybrid protein | 3.36 | 1.04E-03 | |
| LIC10996 | EAL-type diguanylate phosphodiesterase | 3.23 | 2.11E-03 | |
| LIC11617 | ArsR family transcriptional regulator | 3.11 | 7.39E-03 | |
| LIC20025 | Cyclic nucleotide binding protein | 2.41 | 4.73E-02 | |
| Intermediary Metabolism and Biosynthesis of Small Molecules | ||||
| LIC13053 | desA | Fatty acid desaturase | 6.72 | 2.98E-11 |
| LIC12981 | Glutathione S-transferase | 4.00 | 2.59E-02 | |
| LIC13397 | phoD | Alkaline phosphatase | 3.21 | 6.13E-04 |
| LIC13085 | coaE | Dephospho-CoA kinase | 3.20 | 1.79E-02 |
| LIC20148 | hol | Heme oxygenase | 3.06 | 3.35E-03 |
| LIC12322 | Glutaconate CoA transferase-like protein | 2.32 | 4.80E-02 | |
| LIC13031 | Aminotransferase | 2.25 | 1.46E-02 | |
| LIC13465 | Gly tRNA | 4.69 | 1.69E-02 | |
| Cell Processes/Transport | ||||
| LIC11694 | TonB-dependent outer membrane receptor | 14.85 | 2.26E-13 | |
| LIC10964 | phuR | TonB-dependent outer membrane hemin receptor | 3.46 | 2.23E-02 |
| LIC20149 | Multidrug-efflux transporter | 2.82 | 4.22E-02 | |
| LIC12992 | sulP | Sulfate permease | 2.81 | 4.05E-03 |
| DNA Metabolism and Cell Division | ||||
| LIC11467 | rcc1 | Regulator of chromosome condensation | 7.80 | 1.92E-03 |
| LIC12737 | Site-specific modification DNA-methyltransferase | 5.12 | 6.37E-11 | |
| LIC12297 | DNA repair protein | 4.55 | 3.80E-02 | |
| LIC10131 | mesJ | Cell cycle protein | 3.41 | 3.62E-04 |
| LIC10252 | Exonuclease | 3.31 | 5.86E-03 | |
| LIC13389 | mutS | DNA mismatch repair protein | 2.56 | 3.80E-02 |
| LIC11479 | xerD | Integrase/recombinase protein | 2.91 | 3.02E-03 |
| Macromolecular Metabolism and Cell Structure | ||||
| LIC10537 | OmpA-like peptidoglycan-associated periplasmic protein | 3.79 | 1.00E-03 | |
| LIC10528 | pbpB | Penicillin-binding protein 3 | 2.46 | 1.99E-02 |
| Miscellaneous | ||||
| LIC10149 | frnE | Polyketide synthase | 4.89 | 1.08E-02 |
| LIC10251 | Rad50-like protein | 3.22 | 4.05E-03 | |
| LIC11850 | rmsE | 16S ribosomal RNA methyltransferase RsmE | 2.41 | 8.14E-03 |
1
Gene designations and protein product descriptions are based on those of [11], [12] and the L. interrogans sv. Copenhageni Genome Project database (http://aeg.lbi.ic.unicamp.br/world/lic/), except where indicated.
2
nnotation based on Setubal et al. [47].
3
Revised annotation based on bioinformatics.