Figure 10. Mutation in C. albicans STP2 causes attenuation of virulence.

Outbred ICR mice were injected via the tail vein with 10⁶ cells of the wild type strain SVC21, stp2Δ mutant strain SVC23, or the STP2 complemented cells resuspended in phosphate buffered saline. Ten animals per strain were used and the animals were monitored for signs of infection as described in Materials and Methods. The statistical analysis showed that the mutant survival curves are significantly different compared to the wild type or the complemented cells, with a P value of 0.0011 and 0.0024, respectively.