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. Author manuscript; available in PMC: 2014 Aug 5.
Published in final edited form as: Mol Pharm. 2013 Jul 17;10(8):2891–2903. doi: 10.1021/mp300599t

Table 1.

Test Conditions for Mutual Inhibition Experiments with Respect to the Glucuronidation of 3HF, 7HF, 4′HF and 3,7,4′THF

Substrate Inhibitor UGT1A1 (μg/ml) Reaction time (min)

Name Concentration(μM) Name Concentration (μM)
3HF
7HF 0.625, 2.5, 5, 10 3,7,4′THF 0, 0.313, 0.625, 1.25, 5 26.54 30~120
4′HF
3HF
3,7,4′THF 0.313, 0.625,1.25,5 7HF 0, 0.625, 2.5, 5, 10 6.62~26.54 15~60
4′HF