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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Chem Biol. 2013 Dec 22;10(2):113–121. doi: 10.1038/nchembio.1429

Figure 5. Human Ces3 (CES1) is more active in adipose tissue of obese and type 2 diabetic individuals.

Figure 5

(a) ABPP profiles of WAT samples from 7 lean, obese, and type 2 diabetic individuals. Note that hCES1 (black arrow) is the most active serine hydrolase present, and that WWL113 (10 μM) inhibits the human homologue of Ces3. Left-most two lanes are lysates of COS-7 cells ectopically expressing hCES1. (b) Bar graph shows quantification of hCES1 activity relative to a Comassie-stained band that is similarly abundant in all samples (loading control). Error bars represent s.e.m. and *p < 0.05 vs. lean controls.