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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: Mol Pharmacol. 2001 Nov;60(5):1057–1063.

Table 1.

The Ki values of tested compounds for [125I]I-AB-MECA (0.15 nM) binding to human A3 adenosine receptors and the dissociation rates (k−1) in the absence and presence of the tested compounds (10 μM). The assay was carried out as described under Experimental Procedures. Data shown are the mean ±S.E. from three independent experiments performed in duplicate.

Ki (nM) k−1 (min −1)
nM
Control 0.042 ± 0.007
VUF8501 739 ± 146 0.043 ± 0.004
VUF8502 96 ± 26 0.024 ± 0.003*
VUF8503 581 ± 82 0.041 ± 0.011
VUF8504 17.3 ± 1.7 0.022 ± 0.004*
VUF8505 307 ± 99 0.044 ± 0.012
VUF8507 204 ± 42 0.021 ± 0.002*
VUF5455 1680 ± 620 0.024 ± 0.003*
PD81723 N.D. 0.046 ± 0.009
CGS15943 185 ± 37 0.045 ± 0.005

N.D., not determined.

*

p < 0.05 compared with control (Student's t test).