Skip to main content
. 2014 Mar 13;9(3):e90480. doi: 10.1371/journal.pone.0090480

Figure 6. LAP optimal waveforms Inline graphic and Inline graphic for the 0D HHM: The Inline graphic approximation of the ionic current is used for a case of very short duration (Inline graphic = 10 Inline graphic) and the Inline graphic approximation is used for a case of long duration (Inline graphic = 5 Inline graphic) (see the Box).

Figure 6

As with the IM, bvp4c was used to numerically solve the BVP of eqn. (34). The figure follows a quite similar format to Fig. 5. Inline graphic can also be assumed higher or lower. All the maximal ionic conductances in the HHM (see also Table 3) are temperature-dependent and are linearly proportional to the coefficient Inline graphic. The 3 solutions shown correspond to the ionic current at Inline graphic (cyan trace), twice higher (thin red dash-dot), or twice lower (thick dashed black) Inline graphic respectively. From eqn. (42) we can see that Inline graphic = 1.6047 (half the nominal) at Inline graphic, and Inline graphic = 6.4188 (twice the nominal) for at Inline graphic. Box: Resting-state Inline graphic and asymptotic-state Inline graphic ionic currents for the 0D HHM; Markers are inserted at the resting and threshold membrane-voltage points, respectively Inline graphic = −77 Inline graphic, Inline graphic = −64.55 Inline graphic and Inline graphic = −52.35 Inline graphic.