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. 2013 Dec 11;3(2):191–201. doi: 10.1016/j.molmet.2013.11.010

Figure 1.

Figure 1

RYGB-enhanced GLP-1 secretion is attenuated in α-Gust−/− mice. RYGB greatly enhanced glucose-stimulated GLP-1 in WT mice and this effect was attenuated in α-Gust−/− mice. Stimulated GLP-1 was reduced in α-Gust−/− WM-sham compared to sham mice. (n=6, sham; n=6, RYGB; n=6, WM-sham). Values are expressed as mean±SEM. One-way ANOVA was used to compare surgical interventions within a genotype. Student's t-test was used to compare the effect of surgical intervention across genotype. ⁎P<.05 versus sham; #P<.05 versus RYGB; @P<.05 α-Gust−/− versus WT.