Figure 5.

RYGB reduces body weight, improves body composition, and increases total energy expenditure in Glp1r^−/− mice. (A) Body weight, (B) fat mass and (C) lean mass were all reduced in Glp1r^−/− mice after RYGB to the level of age-matched lean C57BL/6 control mice [Lean (C57)]. (D) Daily intake was reduced in Glp1r^−/− mice through post-operative day 18 compared to shams, but no difference was observed thereafter. (E) Feeding efficiency was decreased and (F) total energy expenditure was increased after RYGB in Glp1r^−/− mice. [n=9, sham; n=9, RYGB; n=7, Lean (C57)]. Values are expressed as mean±SEM. Student's t-test was used to compare RYGB-treated Glp1r^−/− mice to Glp1r^−/− shams and Lean (C57) controls. ^⁎P<.05, versus sham; NS=not significant.