Table 1.

Peripheral GLP-1 levels in WT and α-Gust^−/− mice. Fasting plasma GLP-1 in WT and α-Gust^−/− mice was collected from tail vein after an overnight fast. Glucose-stimulated plasma GLP-1 was collected 5 min after administration of 1.5 g/kg of d-glucose via oral gavage through a feeding tube in both genotypes. (n=6, sham; n=6, RYGB; n=6, WM-sham). Values are expressed as mean±SEM. One-way ANOVA was used to compare surgical interventions within a genotype. Student's t-test was used to compare the effect of surgical intervention across genotype.

	Fasting GLP-1 (pg/mL)			Stimulated GLP-1 (pg/mL)
	Sham	RYGB	WM-Sham	Sham	RYGB	WM-Sham
WT	<assay	13.0±4.3	<assay	21.6±3.2	117.6±32.8⁎	8.8±2.3#
α-Gust−/−	<assay	2.7±0.4	<assay	8.1±1.2	14.3±2.4⁎	1.6±0.2⁎#

bolding, P<.05 α-Gust^−/− versus WT.

^⁎P<.05 versus sham.

^#P<.05 versus RYGB.