Table 1.
Characteristics of the participants.
| FTO SNP rs8050136 | CC | CA | AA | punadjusted | padjusted |
|---|---|---|---|---|---|
| Gender (female/male) | 6/4 | 5/5 | 1/3 | 0.5 | – |
| Age (yr) | 24±3 | 24±3 | 23±1 | 0.5 | – |
| BMI (kg/m2) | 26.8±4.9 | 24.9±5.3 | 25.6±5.2 | 0.6 | – |
| Fasting glucose (mmol/l) | 4.8±0.4 | 5.0±0.3 | 5.2±0.3 | 0.0419 | 0.0229 |
| Glucose120 min (mmol/l) | 5.7±1.1 | 6.1±1.8 | 4.1±0.8 | 0.1 | 0.3 |
| AUC Glucose (mmol/l) | 12.8±2.2 | 14.5±2.6 | 11.8±1.6 | 0.9 | 0.9 |
| Fasting insulin (pmol/l) | 64±36 | 54±31 | 49±32 | 0.4 | 0.8 |
| Insulin30 min (pmol/l) | 582±222 | 719±338 | 615±256 | 0.7 | 0.4 |
| Insulin120 min (pmol/l) | 326±182 | 482±349 | 168±62 | 0.5 | 0.8 |
| AUC Insulin (pmol/l) | 805±260 | 1177±713 | 676±165 | 0.9 | 0.6 |
| Insulin sensitivity index, OGTT-derived (AU) | 15.4±8.3 | 14.1±8.4 | 17.9±6.7 | 0.7 | 0.5 |
| HOMA-IR (mmol/l×µU/ml) | 1.90±1.15 | 1.68±0.10 | 1.59±1.10 | 0.6 | 0.9 |
| HbA1c (%) | 5.4±0.2 | 5.4±0.3 | 5.1±0.1 | 0.1 | 0.6 |
Data are given as means±SD. punadjusted=p-values of the comparison of unadjusted loge-transformed data by ANOVA. Distribution of gender was compared by chi-square test. padjusted=p-values of the comparison of loge-transformed data adjusted for gender, age, BMI by multiple linear regression analyses. AUC – area under the curve; FTO – fat mass- and obesity-associated, HOMA-IR – homeostatic model assessment of insulin resistance, OGTT – oral glucose tolerance test.