Table 3.

Association of top CAC SNPs¹ with myocardial infarction in PROMIS

SNP	*Race	Chr	Locus	Effect	PROMIS (N=14,885)
				Allele	OR	95% CI	#P
SNPs with effect estimates in same direction for CAC and MI
rs4977574	Both	9	9p21	A	0.85	0.81–0.89	5.70E-12
rs2891168	Both	9	9p21	A	0.85	0.81–0.89	7.70E-12
rs10757278	Both	9	9p21	A	0.85	0.82–0.89	2.20E-11
rs10757272	Both	9	9p21	A	1.17	1.11–1.22	8.10E-11
rs10757274	Both	9	9p21	A	0.82	0.76–0.88	6.80E-08
rs11105354	EA	12	ATP2B1	A	0.9	0.86–0.95	3.30E-05
rs13260	EA	13	COL4A1	A	0.87	0.8–0.94	9.70E-04
rs3789422	EA	1	ABCA4	A	1.2	1.03–1.4	0.02
rs4946932	EA	6	FOXO3	A	0.96	0.92–1.01	0.09
rs7904918	EA	10	ACSL5	A	1.04	0.99–1.09	0.15
rs2868095	AA	20	HNF4A	A	1.03	0.98–1.09	0.23
rs11236998	AA	11	PHCA	A	0.96	0.87–1.06	0.46
rs2834669	Both	21	RUNX1	A	1.04	0.94–1.15	0.46
rs12613413	EA	2	MAP3K2	A	0.99	0.94–1.03	0.56
rs7964239	Both	12	BCAT1	A	0.99	0.94–1.04	0.7
rs4456611	AA	18	BCL2	A	0.99	0.95–1.04	0.82
rs1635502	Both	1	EXO1	A	1	0.95–1.05	0.9
SNPs with effect estimates in opposite direction for CAC and MI
rs7134070	AA	12	ADIPOR2	A	0.92	0.83–1.01	0.09
rs3766332	AA	1	PTGFR	A	0.95	0.9–1.01	0.11
rs12374310	Both	4	PPARGC1A	C	1.05	0.98–1.13	0.16
rs10499276	Both	6	LOC729635	A	0.93	0.83–1.03	0.18
rs17056112	Both	8	ADRA1A	A	0.94	0.84–1.04	0.22
rs13386681	EA	2	ATOH8	A	1.02	0.97–1.08	0.44
rs6667260	Both	1	ITPKB	A	0.99	0.94–1.03	0.58
rs12132247	Both	1	GNG12	A	1.01	0.95–1.06	0.82
rs3768991	Both	2	NPAS2	A	1	0.96–1.05	0.86
rs3943258	AA	18	BCL2	A	1	0.95–1.04	0.9

¹SNPs with suggestive association with CAC in CRIC as per Table 2. Data not available for rs1436606.

^*Race: AA = African Ancestry; EA = European Ancestry; Both = European and Ancestry.

^#Two-sided P value.