TABLE 4.
Risk of any and hip fracture per 20% increase in calibrated protein intake (percentage of kcal) in the WHI at subgroup levels1
| Outcome | Any fracture | P-interaction | Hip fracture | P-interaction |
| Overall | 0.99 (0.97, 1.02) | — | 0.91 (0.84, 1.00) | — |
| Age at baseline | 0.106 | 0.429 | ||
| 55 y | 1.02 (0.96, 1.07) | 0.90 (0.75, 1.05) | ||
| 65 y | 0.99 (0.96, 1.01) | 0.91 (0.82, 0.99) | ||
| 75 y | 0.96 (0.91, 1.02) | 0.92 (0.83, 1.02) | ||
| BMI | 0.035 | 0.191 | ||
| 18.5 kg/m2 | 0.95 (0.90, 1.00) | 0.87 (0.74, 1.00) | ||
| 25.0 kg/m2 | 0.98 (0.95, 1.00) | 0.91 (0.83, 0.99) | ||
| 30.0 kg/m2 | 1.00 (0.97, 1.03) | 0.94 (0.85, 1.05) | ||
| 35.0 kg/m2 | 1.02 (0.98, 1.07) | 0.97 (0.83, 1.15) |
1
All values are HRs; 95% CIs in parentheses. HRs were derived from Cox proportional hazard regression models adjusted for age, BMI, race-ethnicity, calibrated energy intake, income, general health, physical activity, history of fracture at age ≥55 y, history of parental fracture, current smoking, corticosteroid use, glucocorticoid use, treated diabetes, rheumatoid arthritis, and hormone use and calculated at the subgroup point of interest. WHI, Women's Health Initiative.