Table II.

Univariate and multivariate analysis with regard to overall survival

Parameter	Univariate analysis	Multivariate analysis
	Value of p	Value of p	RR (95% CI)
Age [years]
< 65 vs. ≥ 65	0.650	0.457	1.188 (0.755–1.868)
Gender
Male vs. female	0.531	0.642	1.115 (0.706–1.760)
Depth
T1/T2 vs. T3/T4	0.123	0.065	0.540 (0.281–1.039)
Lymph node metastasis
Yes vs. no	< 0.001	< 0.001	3.597 (1.875–6.902)
Histology
Differentiated vs.undifferentiated	0.303	0.579	1.119 (0.753–1.664)
TNM stage
1/2 vs. 3/4	0.006	0.187	1.375 (0.857–2.205)
Vascular infiltration
Yes vs. no	0.035	0.109	1.495 (0.914–2.447)
Lymphatic vessel infiltration
Yes vs. no	0.041	0.995	1.002 (0.616–1.628)
Phospho-PRAS40Thr246
Positive vs. negative	< 0.001	0.004	1.883 (1.231–2.880)