Figure 1.

Inhibitor classes and the cellular energy consequences of LCH inhibitors. Presented are examples from three main classes of inhibitors and the ways cells can cope with these: efflux via pumps, detoxification via enzymes, and repair of the damage caused by the compounds. Each coping strategy comes at the expense of cellular energy that is diverted from the stores used to maintain cell integrity by chemiosmotic exchange and assimilation as well as energy required for fermentation of sugars to fuel.