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. 2010 Sep 14;1(2):283–293. doi: 10.3390/genes1020283

Figure 2.

Figure 2

Immunohistochemical localization of TSPY and other biomarkers in the prostate tissues. (a) Immunostaining of TSPY (brown) in prostatic adenocarcinoma. Nuclei were counterstained by hematoxylin (purple). Note significant TSPY staining in cancer cells (red arrowheads), and faint or negative staining in the surrounding stromal cells (blue arrows). ‘NP’ indicates the TSPY-positive normal prostate gland. (b) Image of normal gland adjacent to cancer area in the same clinical prostate cancer section of (a). Epithelial cells in normal gland were also positively stained (arrows). (c) Representative image of TSPY immunostaining in the TSPY-negative gland of normal prostate. (d) Clinical prostate cancer section doubly immunostained for AMACR (dark blue) and p63 (brown). Arrow indicates the morphologically normal glands containing AMACR-negative epithelial cells and p63-positive basal cell layers. ‘PCa’ indicates the AMACR positive cancer area. (e) An adjacent section of d immunostained by anti-TSPY. Arrows indicate the AMACR-negative glands that were expressing TSPY. Scale bar = 75 μm.