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. 2014 Mar 14;6:42. doi: 10.3389/fnagi.2014.00042

Figure 3.

Figure 3

Select brain-penetrating polyphenolic metabolites from GSE and Concord grape juice are bioactive in preventing acute oAβ-induced LTP impairment. Ex vivo hippocampal slices from wild type (WT) mice were acclimated in oxygenated artificial cerebrospinal fluid and challenged with (A) 200 nM of oAβ (B) 200 nM oAβ co-treated with 3′-O-Me-EC-Gluc (300 nM), (C) 200 nM oAβ co-treated with cyanidin-Glur (300 nM) and (D) 200 nM oAβ co-treated with resveratrol (20 μ M) for 1 h before recording. The fEPSPs were recorded from the CA1 region. The fEPSP slopes (% of baseline) were plotted as a function of time. The arrows indicate the beginning of tetanus used to induce LTP. Inset in (A), representative EPSP traces for vehicle (left) and oAβ (right) treated slices: Red trace represents pre-LTP and black trace represents 60 min following tetanus stimuli. Insets in (B) and (C), average magnitude of LTP during the last 5 min of recording. Data represents mean ± s.e.m., **P < 0.01.