CD-1 mice were habituated to activity chambers for 50 min, pretreated with
vehicle or l-ICP (1, 3 and 10 mg/kg, i.p.) for 10 min followed
by saline or cocaine (20 mg/kg, i.p.) as described in Methods.
Areas under curves (AUCs) were calculated for (A) total activity,
(B) ambulatory activity and (C) repetitive
non-ambulatory activity. Each value represents mean ± s.e.m
(n=16 for veh/saline, n= 10 for all other groups).
**P<0.01,
***P<0.001, compared with
the veh/cocaine group;
+++P<0.001,
+P<0.05 compared with
veh/saline, both by two-way ANOVA followed by Bonferroni post hoc test.