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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Drug Alcohol Depend. 2013 Sep 2;133(2):693–703. doi: 10.1016/j.drugalcdep.2013.08.021

Figure 6. Effects of l-ICP on development of locomotor sensitization induced by repeated cocaine treatment in mice.

Figure 6

(A) Timeline of the experimental procedure and drug treatment. (B) Locomotor activities on Day 1 and Day 5. (C) Locomotor activities on Day 13. From day 1 to day 5, mice were treated once/day with vehicle or l-ICP (10 mg/kg, i.p.) followed by saline or cocaine (20 mg/kg, i.p.)10 min later as described in Methods. Following withdrawal from day 6 to day 12, on day 13, mice were challenged with cocaine. Activities were monitored on days 1, 5 and 13 for 120 min. The areas under curves of total activities (0-60 minutes) are shown in the B and C. Each value represents mean ± s.e.m (N=8 for each group).

*** P<0.001 and *P<0.05 compared with veh/COC; ++P<0.01 and +P<0.05, compared with day 1 veh/cocaine by two-way ANOVA followed by Bonferroni post hoc test.