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. 2014 Mar 13;55(3):1509–1518. doi: 10.1167/iovs.13-13633

Figure 5.

Figure 5

Activation of the Noncanonical BMP signaling by p120-Kaiso siRNAs. Human corneal epithelial cell monolayers treated by different knockdown regimens for 2 days before qRT-PCR analysis of transcript expression of BMP ligands and bone morphogenic protein receptors ([A], *P < 0.05 and **P < 0.01 compared with the scRNA control), ID1-4 ([B], all P > 0.05 compared with the scRNA control), and immunostaining of pSMAD1/5/8 [C], scale bar: 100 μm). Over-expression of BMP2, BMP4, and BMPR1B transcript by p120-Kaiso siRNAs was challenged by various small molecular weight inhibitors and Noggin ([D], *P < 0.05 and **P < 0.01 compared with the scRNA control).