Table III. Magnitudes of association among combined test results and intra-amniotic inflammation and histologic acute chorioamnionitis.
| Intra-amniotic inflammation | Histologic acute chorioamnionitis | |||||
|---|---|---|---|---|---|---|
| OR | 95%CI | OR | 95%CI | |||
| Unadjusted | ||||||
|
| ||||||
| PCR/ESI-MS (+) – AF (+) | 31.7 | 1.5 | 691 | 25.8 | 1.1 | 591 |
| PCR/ESI-MS (+) – AF (-) | 13.4 | 2.1 | 85 | 4.3 | 1.1 | 17 |
| PCR/ESI-MS (-) – AF (+) | 0.3 | 0.01 | 9 | 1.2 | 0.1 | 13 |
| PCR/ESI-MS (-) – AF (-) | 1 | reference | 1 | reference | ||
|
| ||||||
| Adjusted* | ||||||
|
| ||||||
| PCR/ESI-MS (+) – AF (+) | 47.8 | 1.8 | >999 | 32.6 | 1.3 | 788 |
| PCR/ESI-MS (+) – AF (-) | 12.2 | 1.5 | 97 | 5.1 | 1.01 | 26 |
| PCR/ESI-MS (-) – AF (+) | 0.9 | 0.02 | 35 | 1.7 | 0.2 | 20 |
| PCR/ESI-MS (-) – AF (-) | 1 | reference | 1 | reference | ||
AF: Amniotic fluid; GE/well: genome equivalent per well; PCR: polymerase chain reaction; ESI-MS: Electrospray ionization mass spectrometry.
*
Note: adjusted for cervical dilation and gestational age at amniocentesis; Firth's penalized maximum likelihood estimation was performed where necessary to resolve separation issues.