Table 2.
Acute toxicity
| RTOG Radiation Morbidity Score | Proton CSI | Photon CSI |
|---|---|---|
| n (%) | n (%) | |
| Nausea/Vomiting* (n=40) | ||
| 0 | 4 (21%) | 2 (10%) |
| 1 | 10 (53%)‡ | 4 (19%)‡ |
| 2 | 5 (26%) | 15 (71%) |
| Dermatitis† (n=40) | ||
| 0 | 0 | 1 (5%) |
| 1 | 19 (100%) | 19 90%) |
| 2 | 0 | 1 (5%) |
| Hemoglobin (n=39) | ||
| 0 (>11 g/dL) | 15 (83%) | 11 (52%) |
| 1 (9.5–11) | 1 (6%)§ | 10 (48%)§ |
| 2 (5–<7.5) | 2 (11%) | 0 |
| White Blood Cells (n=39) | ||
| 0 (≥4 × 109/L) | 3 (17%) | 5 (24%) |
| 1 (3–<4) | 5 (28%) | 4 (19%) |
| 2 (2–<3) | 10 (56%) | 10 (48%) |
| 3 (1–<2) | 0 | 2 (10%) |
| Platelets (n=39) | ||
| 0 (≥100 × 109/L) | 16 (89%) | 15 (71%) |
| 1 (75–<100) | 1 (6%) | 5 (24%) |
| 2 (50–<75) | 1 (6%) | 0 |
| 3 (25–<50) | 0 | 0 |
| 4 (<25) | 0 | 1 (5%) |
| Weight loss (n=33) | ||
| ≤2% | 12 (63%) | 3 (21%) |
| >2–5% | 4 (21%)|| | 2 (14%)|| |
| >5%–10% | 3 (16%)¶ | 8 (57%)¶ |
| >10% | 0 | 1 (7%) |
| Blood counts at start of CSI | Median (Range) | Median (Range) |
| White blood cells | 5.9 (2.3–20.9) | 7.2 (2.6–15.8) |
| Hemoglobin | 13.5 (9.4–16) | 13.6 (10.7–16.2) |
| Platelets | 219 (136–396) | 258 (123–517) |
Abbreviations: CSI= Craniospinal irradiation
*
Grade 1: not requiring antiemetics; 2: requires antiemetics
†
Grade 1: faint erythema, dry desquamation; 2: bright erythema, patchy moist desquamation
‡
p= 0.004 comparing grade 2 or greater nausea/vomiting
§
p= 0.04 comparing grade 1 or greater anemia
||
p= 0.02 comparing weight loss greater than 2%