Table 1.
Effect of the eight prostamide receptor antagonists examined in this study on various prostanoid receptors and the prostamide F2α receptor
| Compound | Prostamide F2α receptors (Kb, μM) | FP (Kb, μM) | DP (Kb, μM) | EP1 (Kb, μM) | EP2 (Kb, μM) | EP3 (Kb, μM) | EP4 (Kb, μM) | IP (Kb, μM) | TP (Kb, μM) |
|---|---|---|---|---|---|---|---|---|---|
| AGN 205492 | 0.17 | 0.20 | 0.55 | 1.2 | NA | 4.5 | 0.32 | 4 | <0.001 |
| AGN 205493 | 0.05 | 0.15 | 0.09 | 0.25 | NA | 3.9 | 0.46 | 4.2 | <0.001 |
| AGN 205494 | 0.5 | 0.03 | 0.009 | 0.03 | 3 | 0.66 | 0.03 | 0.48 | <0.001 |
| AGN 204396 | 2.6 | NA | NA | NA | NA | NA | NA | NA | 0.001 |
| AGN 204397 | 3.1 | NA | NA | NA | NA | NA | NA | NA | 0.001 |
| AGN 211334 | 0.24 | NA | NA | NA | NA | NA | NA | NA | 0.02 |
| AGN 211335 | 0.35 | NA | NA | NA | NA | NA | NA | NA | 0.10 |
| AGN 211336 | 0.3 | NA | NA | NA | NA | NA | NA | NA | 0.11 |
See Methods for the description of assay conditions.