Table 1.
Control | LPS | LPS + HU308 | LPS + AM630 | LPS + AM630 + HU308 | |
---|---|---|---|---|---|
TNF-α | 5.9 ± 4.1* | 52.6 ± 18.12+ | 0.82 ± 0.6* | 16.8 ± 7.1* | 5.9 ± 4.2* |
IL-1β | 264.2 ± 71.4* | 5572 ± 1076+ | 603 ± 214* | 3564 ± 1453+ | 550 ± 137* |
IL-6 | 8.9 ± 2.2* | 32.9 ± 5.1+ | 7.5 ± 2.3* | 16.5 ± 3.7* | 7.2 ± 2.3* |
IL-10 | 11.1 ± 1.8 | 18 ± 1.5 | 6.9 ± 1.3* | 14.2 ± 3.0 | 12.9 ± 2.7 |
IFN-γ | 1.3 ± 0.4 | 2.5 ± 3.8 | 0.8 ± 0.4* | 1.4 ± 0.4 | 1.2 ± 0.6 |
CCL5 | 53.2 ± 17.9* | 289 ± 49+ | 66.2 ± 17.1* | 192 ± 57.3+ | 51.1 ± 13.2* |
CXCL2 | 101 ± 34.6* | 2023 ± 418+ | 213 ± 58.7* | 852 ± 362* | 288 ± 102* |
sVCAM | 214 ± 34.3 | 363 ± 50.5 | 191 ± 27.1 | 360 ± 82 | 244 ± 43.4 |
ICAM | 1304 ± 234 | 2118 ± 368 | 1208 ± 116 | 2333 ± 557 | 1589 ± 271 |
Data shown (mean ± SEM) are from control, LPS and LPS with treatments with CB receptor ligands: CB2 receptor agonist, HU308, CB2 receptor antagonist AM630 and combination of AM630 + HU308, n = 8–11,P < 0.05 to control, *P < 0.05 compared with LPS.