Table 2.
Levels of inflammatory mediators (pg·mL−1) in extracts of the iris and ciliary body
| LPS | LPS + dexamethasone | LPS + prednisolone | LPS + nepafenac | |
|---|---|---|---|---|
| TNF-α | 52.6 ± 18.1+ | 31.6 ± 21.3 | 24.7 ± 13.1 | 15.4 ± 6.7 |
| IL-1β | 5572 ± 1076+ | 2639 ± 798 | 2381 ± 1203* | 2888 ± 947 |
| IL-6 | 32.9 ± 5.1+ | 29.7 ± 9.9+ | 24.8 ± 5.6 | 14.5 ± 5 |
| IL-10 | 18 ± 1.5 | 16.53 ± 2.7 | 16.5 ± 6.2 | 13.5 ± 2.0 |
| IFN-γ | 2.5 ± 3.8 | 1.3 ± 0.5 | 2.1 ± 0.9 | 2.2 ± 0.8 |
| CCL5 | 289 ± 49+ | 196 ± 57 | 143 ± 49 | 277 ± 69+ |
| CXCL2 | 2023 ± 418+ | 1994 ± 852+ | 1199 ± 365 | 1340 ± 531 |
| sVCAM | 363 ± 50.5 | 410 ± 81.6 | 390 ± 142 | 381 ± 41.2 |
| ICAM | 2118 ± 368 | 2174 ± 352 | 2676 ± 926 | 2616 ± 393 |
Data shown (mean ± SEM) are from control, LPS and LPS with dexamethasone, prednisolone or nepafenac treatments for uveitis, n = 7–11,P < 0.05 to control, *P < 0.05 compared with LPS.