Skip to main content
. 2014 Mar 4;171(6):1510–1520. doi: 10.1111/bph.12543

Figure 4.

Figure 4

Pharmacological or genetic blockade of TRPV1 function abolishes LE135-induced thermal hyperalgesia. Time course of thermal hypersensitivity in animals treated with LE135. Intraplantar injection of LE135 (30 nmol/10 μL, red trace) induced thermal hyperalgesia in Trpv1+/+ mice as reflected by a decrease in paw withdrawal latency. Administration of AMG9810 (10 mg kg−1, i.p.,) removed the effect of LE135. LE135-elicited thermal hypersensitivity was also abolished in Trpv1−/− mice. *** P < 0.001 versus vehicle; +++ P < 0.001 versus AMG9810; and ### P < 0.001 versus Trpv1−/−. Please note that no effect was observed upon injection of vehicle alone. n = 5–10 animals per condition.