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. 2014 Mar 4;171(6):1534–1550. doi: 10.1111/bph.12562

Figure 3.

Figure 3

Pharmacological manipulation of NaHS-induced responses in rat duodenal muscle strips. (A) Representative recordings of the effects of different pretreatments on the responses of duodenal muscle strips to NaHS (1 mM). DMSO or NS acted as the vehicle control for the different chemicals. The horizontal lines indicate different chemical pretreatment and the arrows indicate NaHS treatment. The summarized data of the effects of the blockers, capsazepine (10 μM), L703606 (10 μM), Glib (10 μM), TTX (10 μM) and L-NAME (0.1 mM), on the biphasic responses to NaHS of duodenal muscle strips are shown in (B) and (C). (B) The normalized motility index (R) of the muscle strips at 1 min following NaHS administration. Capsazepine and L703606 pretreatment attenuated the excitatory effect of NaHS on the spontaneous contractions but TTX, L-NAME and Glib did not. (C) Summarized data of R at 15 min after application of NaHS. (D) and (E) Summarized data of R at 1 min and 15 min after application of NaHS respectively. A784168 (0.3 μM) and SB-366791 (1 μM) pretreatment attenuated the excitatory effect of NaHS (0.6 mM) on the spontaneous contractions. #P < 0.05 versus DMSO.