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Effects of 2-BFI alone and in combination with morphine on CFA-induced mechanical hyperalgesia in rats. Left: dose–effect curves for 2-BFI alone and 2-BFI/morphine under a fixed proportion of 1:1. Right: isobologram for 2-BFI/morphine mixture. Abscissa scale: ED50 value of morphine. Ordinate scale, ED50 value of 2-BFI (n = 6 per group).
