Table 2. MAT Binding Data for Thio- and Sulfinylethanamine Analogues^a.

				Ki [SE interval] (nM)
compd	X	Y	R	DAT	SERT	NET
6a	H	S	H	142 [131–155]	221 [191–257]	980 [938–1020]
6b	Cl	S	H	296 [272–323]	29.8 [28.2–31.5]	6920 [6340–7550]
6c	Br	S	H	483 [434–536]	26.1 [23.9–28.5]	8540 [7980–9130]
6d	H	S	cyclopropylmethyl	435 [406–466]	10000 [9570–10400]	17300 [15400–19400]
6e	H	S	n-butyl	310 [275–350]	5700 [5040–6440]	11500 [10700–12300]
6f	H	S	3-phenylpropyl	295 [268–325]	927 [786–1090]	5500 [5140–5880]
6g	F	S	3-phenylpropyl	114 [97.4–132]	354 [312–402]	3850 [3830–3870]
6i	Br	S	3-phenylpropyl	613 [564–667]	163 [156–170]	3160 [2950–3390]
7a	H	S=O	H	1110 [1020–1200]	3380 [2970–3820]	24500 [22800–26200]
7b	H	S=O	n-butyl	1570 [1490–1660]	63600 [56100–72200]	138000 [103000–184000]
7c	F	S=O	3-phenylpropyl	183 [140–239]	1280 [1100–1480]	3270 [3130–3420]
7d	Cl	S=O	3-phenylpropyl	645 [565–736]	553 [513–595]	5670 [5000–6420]
7e	Br	S=O	3-phenylpropyl	1270 [1130–1420]	557 [493–628]	8650 [7450–10000]
2b	H	S=O	3-phenylpropyl	192 [177–209]	987 [870–1120]	2320 [2060–2620]

^aEach K_i value represents data from at least three independent experiments, each performed in triplicate. K_i values were analyzed by PRISM. Binding assays are described in detail in the Experimental Methods.

^bPreviously reported by Cao et al.¹⁰