. 2014 Feb 7;16(4):1072–1075. doi: 10.1021/ol4034868

Table 1. Optimization of the Tandem NCR Cyclization^a.

graphic file with name ol-2013-034868_0007.jpg

temp (°C)	solvent	addition time (h)	% yield (isolated)
80	Ph-Me	0	40–50
21 (sunlamp)	Ph-Me	0	17
80	Ph-CF₃	0	27
80	Ph-Me	1	61 (+Cl· transfer pdt.)
80	Ph-H	1	21
110	Ph–Me	1	74

All reactions were performed using 0.5 equiv of AIBN, 2 equiv of Bu₃SnH, at 0.01 M. Addition over 1 h indicates a solution of AIBN and Bu₃SnH was added dropwise over 1 h to a heated solution of the substrate in the indicated solvent.

Table 1. Optimization of the Tandem NCR Cyclizationa.

Table 1. Optimization of the Tandem NCR Cyclization^a.